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The utilisation of observational healthcare data has become increasingly important in evidence-based medicine and healthcare research. Researchers, clinicians, and policymakers leverage this data to study disease patterns, treatment effectiveness, patient outcomes, and healthcare utilisation on a large scale. However, the heterogeneity and variability in data sources, formats, and standards pose significant challenges to the meaningful analysis and interpretation of observational healthcare data.
This is where a Common Data Model (CDM) becomes crucial. A CDM is a standardised framework that structures and consistently organises observational healthcare data, facilitating interoperability and comparability across different datasets.
One of these CDMs is The Observational Medical Outcomes Partnership Common Data Model, commonly known as the OMOP CDM, which is designed to organise and harmonise healthcare data for observational research. Developed by the Observational Health Data Sciences and Informatics (OHDSI) collaborative, the OMOP CDM provides a common language and structure for representing diverse healthcare data sources, enabling researchers to conduct large-scale analyses across different datasets.
At its core, the OMOP CDM defines a set of tables and relationships that standardise the representation of clinical data, such as patient demographics, medical conditions, treatments, and outcomes. This standardised format allows researchers to seamlessly integrate data from various healthcare databases, regardless of their source or format. By ensuring a consistent structure, the OMOP CDM promotes interoperability and facilitates the pooling of data for robust observational studies and analyses.
Healthcare databases often differ in terms of data structure, coding systems, and clinical practices, making it challenging to harmonise data across diverse sources. The process of mapping and standardising these varied data elements to the OMOP CDM requires meticulous attention to detail and a deep understanding of clinical concepts.
Observational studies inherently introduce biases, confounding variables, and other complexities that differ from the controlled environment of clinical trials. Researchers working with OMOP data must carefully consider these nuances to draw accurate conclusions and make informed decisions, especially when the stakes involve public health or regulatory considerations.
OMOP databases encompass a vast array of patient information, including electronic health records, claims data, and other real-world evidence. Managing and analysing such extensive datasets demands robust computational infrastructure and sophisticated analytical techniques. Researchers must grapple with issues related to data storage, processing speed, and the scalability of their analytical methods to extract meaningful insights from these rich datasets efficiently.
The Aridhia DRE provides a secure and scalable platform for data ingestion, transformation, validation, and quality control, making it the ideal platform to support the entire OMOP journey all the way through to data analysis. Aridhia are a European Health Data and Evidence Network (EHDEN) SME, and supports the OMOP ETL journey for a number of DRE customers, including Great Ormond Street Hospital and the Sydney Children’s Hospital Network.
To transform health records into an OMOP source, a series of ETL (extract, transform, load) pipelines are needed. These pipelines involve:
The technologies that can be used to implement these ETL pipelines vary depending on the source and target systems, but some common ones are:
The Aridhia DRE allows data owners to share their OMOP data with authorised researchers, who can access and analyse the data using a variety of tools and methods within the DRE:
Each Aridhia DRE workspace provides an out-of-the box RStudio and Jupyter Notebook application, without the need to use a virtual machine, saving on platform costs while providing researchers with the tools they are familiar with, along with in-built data analysis modules and a no-code SQL development environment. OMOP data can be large and a zero-transfer approach to working with this data can be enabled, allowing for direct read-only access to approved cohorts of OMOP data from workspace applications, including specialist R Shiny applications.
While OMOP and its Common Data Model offer a promising avenue for advancing observational research in healthcare, researchers must navigate a landscape fraught with challenges. Addressing issues related to data harmonisation, scalability, and result interpretation is crucial for unlocking the full potential of OMOP data and realising its impact on improving patient outcomes and healthcare delivery. The Aridhia DRE provides a secure, scalable end-to-end platform to support the entire OMOP data journey, from transformation, to analysis.