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Digital Research Environment (DRE)-Enabled Artificial Intelligence (AI) to Facilitate Early Stage Drug Development.

Early-stage drug discovery is highly dependent upon drug target evaluation, understanding of disease progression and identification of patient characteristics linked to disease progression overlaid upon chemical libraries of potential drug candidates. Artificial intelligence (AI) has become a credible approach towards dealing with the diversity and volume of data in the modern drug development phase.

There are a growing number of services and solutions available to pharmaceutical sponsors though most prefer to constrain their own data to closed solutions given the intellectual property considerations. Newer platforms offer an alternative, outsourced solution leveraging sponsors data with other, external open-source data to anchor predictions (often proprietary algorithms) which are refined given data indexed upon the sponsor’s own chemical libraries.

Digital research environments (DREs) provide a mechanism to ingest, curate, integrate and otherwise manage the diverse data types relevant for drug discovery activities and also provide workspace services from which target sharing and collaboration can occur providing yet another alternative with sponsors being in control of the platform, data and predictive algorithms. Regulatory engagement will be essential in the operationalizing of the various solutions and alternatives; current treatment of drug discovery data may not be adequate with respect to both quality and useability in the future.

More sophisticated AI/ML algorithms are likely based on current performance metrics and diverse data types (e.g., imaging and genomic data) will certainly be a more consistent part of the myriad of data types that fuel future AI-based algorithms. This favors a dynamic DRE-enabled environment to support drug discovery. Part of Aridhia’s 2024 mission will also be to establish MOUs with several key vendors and collaborators in the AI platform space including Verisim Life, Pumas AI and Quinten Health.

You can find the full text for the publication below.

Barrett JS, Eradat Oskoui S, Russell S, Borens A

Front. Pharmacol. 14:1115356

doi: 10.3389/fphar.2023.1115356

PMID: 37033647

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